Immunotherapy or Allergy Desensitization or Allergy Shots

Allergy shots is the term often used for allergen immunotherapy treatment , or allergy vaccination . Allergen immunotherapy is an effective vaccination program that can increase your immunity to substances called allergens that trigger your symptoms.

Allergen immunotherapy involves administering gradually increasing amounts of an allergen to a patient over several months. The injections are first given on a weekly or bi-weekly basis, and when the maintenance level is reached, eventually on a monthly basis. This process reduces symptoms that are otherwise triggered by allergen exposure. Immunotherapy treatment is the closest thing to a “cure” for allergic symptoms, because once you reach a maintenance dose of allergen vaccine or have finished your course of treatment, your symptoms are typically greatly reduced.

How does treatment work?

If you are allergic to a substance such as ragweed pollen, you will not overcome your allergy by repeatedly inhaling ragweed into your nose or lungs. So, how can increasing your exposure to the substances that trigger your allergies—such as ragweed or cat allergens—help you?

Allergen immunotherapy works like a vaccination. Through your body’s exposure to small, injected amounts of a particular allergen, in gradually increasing doses, your body builds up an immunity to the allergen(s) to which you are allergic. This means that when you encounter these allergens in the future, you will have a reduced or very minor allergic response and fewer symptoms.

At the beginning of allergen immunotherapy, the first injection consists of a small amount of the least concentrated vaccine, or a diluted solution of the allergen vaccine. Each week, the patient receives a slightly more concentrated allergen vaccine injection. The rate at which this concentration is increased depends on the patient’s degree of sensitivity. Usually a patient will reach the top (maintenance) dose about four to six months after injections are begun. The maintenance dose is then given every one to two weeks, and later, the interval usually is extended to every three or four weeks.

If you begin allergen immunotherapy treatment, it is very important to continue your injections on a regular basis until the treatment is discontinued. Otherwise, the treatment will not be beneficial. Generally, patients receive injections for three to five years or longer. After that, their sensitivity to the particular allergen to which they are allergic is reduced, often for years following discontinuation of therapy. This can mean, for instance, that they may be able to tolerate the outdoors during specific pollinating seasons without experiencing symptoms.

Allergen immunotherapy works by altering the abnormal immune responses that cause allergy. Protective antibodies, similar to those made in response to other vaccines, play a role in the beneficial results of allergen injection therapy.

Benefits

Allergen immunotherapy treatment is considered when allergy symptoms are moderate to severe, occur throughout most of the year, do not respond adequately to medications, and are triggered by an allergens not easily avoided, such as pollens or house dust mite allergens.

For example, if you are extremely allergic to both grass and ragweed pollens, you may experience intolerable symptoms such as sneezing, a runny nose, and itchy, red eyes and nose during the spring and fall. It is impossible, or at least impractical, for you to completely avoid these common, airborne allergens. Although air conditioning will help decrease indoor pollen exposure, and medications may be helpful, you may find you still experience symptoms for prolonged periods at those times of the year.

For such a patient, allergen immunotherapy with grass and ragweed allergens will provide significant relief. Some other allergens used for allergen immunotherapy include tree pollens, molds, dust mites, cat and dog allergens, and stinging insect venoms.

Potential side effects

As you can see, allergen immunotherapy can be beneficial for many allergic patients. However, there are also some drawbacks. Some patients may find repeated visits to their allergist (or other physician who administers their injections) to be inconvenient. Also, as with all treatments, some patients may experience adverse reactions, i.e., the injection can sometimes cause an allergic reaction.

After you receive each injection, your allergist or other physician administering your injection will require that you remain in the clinic for 20 minutes or longer so the staff can monitor you. During treatment, some patients develop swelling at the site of the injection. When these are large, they are called “local reactions.” Oral antihistamines, ice packs and adjustment of the dose or vaccine resolves these reactions.

Rarely, a patient may have a more serious allergic reaction, resulting in asthma symptoms or anaphylaxis. Asthma symptoms include cough, wheezing and shortness or breath. Symptoms of an anaphylactic reaction can include sneezing, watery nasal discharge, itchy eyes, swelling in the throat, wheezing or a sensation of tightness in the chest, nausea, dizziness or other symptoms. Such reactions require immediate treatment. If not appropriately treated, these reactions may become serious. Your allergist is trained to monitor for such reactions—that is why you are asked to remain in the clinic for 20 minutes or more after your injection.

In summary, allergen immunotherapy is a vaccination treatment program that is highly effective for allergic patients. It is the closest thing to a “cure” for those who have allergic rhinitis or “hay fever,” allergic asthma caused by allergens such as mites and pollens, and stinging insect allergy. Such therapy provides relief to many allergy sufferers who cannot avoid the allergens to which they are allergic.

Fact Sheet: Efficacy and Safety of Immunotherapy

Immunotherapy, provided by qualified physicians, is an effective and safe treatment for asthma, allergic rhinitis and insect venom allergy.

Effective treatment for asthma

A meta-analysis of 20 published prospective studies showed that allergen immunotherapy is effective in the treatment of asthma.(1) The American College of Allergy, Asthma & Immunology (ACAAI) recently compiled an annotated bibliography of 59 articles from the medical literature indicating the value of expert care and immunotherapy for asthma.(2) A meta-analysis of 23 published studies involving 935 asthmatic patients with documented allergy indicated that immunotherapy is effective in a selected population of allergic asthmatic patients.(3)

Effective treatment for allergic rhinitis

An extensive review of immunotherapy for allergic rhinitis in children showed that the only treatment able to affect the natural cause of the disease is immunotherapy, and that immunotherapy may prevent the onset of asthma.(4) A meta-analysis of 18 published studies involving 789 patients concluded that immunotherapy is highly effective in the treatment of allergic rhinitis.(5)

Effective treatment for insect venom allergy

Immunization with insect venom is an extremely effective treatment for preventing future systemic reactions to insect stings in individuals with previously demonstrated susceptibility.(6) A meta-analysis of nine published studies indicated that a course of immunotherapy is highly effective in the management of insect sting hypersensitivity.(7)

Immunotherapy safety

A report from the Mayo Clinic on 79,593 immunotherapy injections over a 10-year period showed the incidence of adverse reactions to be less than two-tenths of 1 percent (0.137 percent). Most of the reactions were mild and responded to immediate medical treatment. There were no fatalities.(8)

More than 1 million injections were given without a fatality to 8,706 patients in allergy clinics at Roosevelt Hospital, New York City, between 1935 and 1955.(9)

Comparative risks of immunotherapy

Nevertheless, rare occurrences of fatal anaphylactic episodes related to immunotherapy continue to be reported and studied. A total of 35 deaths following immunotherapy administration were reported for the years 1985 through 1993. It has been estimated that during that period there were 52.3 million immunotherapy procedures, making the incidence of fatality less than one per million (0.6692 per million).(10) Data recently compiled by the Allergen Products Manufacturers Association (APMA) estimated the incidence of fatalities to be about three per 190 million annual injections, or approximately one per 63 million injections.(11) Another study evaluating 13 international fatalities related to immunotherapy between 1992 and 1996 identified an elevated risk for patients with active asthma and being switched to high doses.(12)

For perspective, it is useful to compare these statistics with the incidence of fatalities related to other kinds of injections. Studies of fatal anaphylaxis reactions to injected penicillin have ranged from 0.4 fatalities per million injections(13), to 1 fatality per 7.5 million injections.(14)

Fatalities related to radiocontrast “dyes” used in intravascular radiologic studies in the early 1980s varied from 1 in 13,000 procedures(15) to 1 in 75,000 procedures.(16) A more recent study showed a substantial improvement to about 1 fatality in 169,000 procedures.(17)

Guidelines for safe and effective immunotherapy

Any immunotherapy fatality, no matter how rare, is unacceptable. To promote immunotherapy safety, the American College of Allergy, Asthma & Immunology offers the following guidelines:

  1. Immunotherapy should be prescribed only by an allergist-immunologist or other physician who is expertly trained in the therapy.
  2. Immunotherapy should be administered under the supervision of an allergist-immunologist or other physician specifically trained in immunotherapy, the early signs and symptoms of anaphylaxis, and appropriate emergency procedures and medications.(18)
  3. Patients must be suitably selected for immunotherapy.
  4. Immunotherapy should be given only in facilities equipped to treat anaphylaxis.
  5. The health status of the patient should be evaluated prior to every injection. Patients who are acutely ill, especially with asthma or respiratory difficulties, should not receive immunotherapy until their disease is stabilized.
  6. Patients should always be asked about current medications prior to immunotherapy, to avoid interactions with beta blockers and other conflicting medications.
  7. Patients must wait at the health care facility a minimum of 20 minutes after an allergen injection. The time period may be extended for high-risk patients.(19, 20)

References

  1. Abramson MJ, Puv RM, Weiner JM. Allergen immunotherapy effective in asthma? A meta-analysis of randomized controlled trials. Am J Respir Crit Care Med 1995;151:969-974.
  2. Sullivan TJ, Selner JC, Patterson R, Portnoy J, Seligman M. Expert Care and Immunotherapy for Asthma. A review of published studies with emphasis on patient outcome and cost. ACAAI Monograph, Nov 1996,1-25.
  3. Ross RR. Effectiveness of immunotherapy in the management of asthma: A meta-analysis of the literature. May 1997. Data on file with American Academy of Allergy, Asthma & Immunology (AAAAI) and American College of Allergy, Asthma and Immunology (ACAAI) and submitted for publication.
  4. Bousquet J, Demoly P. Specific immunotherapy for allergic rhinitis in children. Allergy Clin Immunol Inter 1996; 8:145-150.
  5. Ross RR. Effectiveness of immunotherapy in management of allergic rhinitis: A meta-analysis of the literature. May 1997. Data on file with AAAAI and ACAAI and submitted for publication.
  6. Valentine MD. Anaphylaxis and stinging insect hypersensitivity. JAMA 1992; 268:2830-2833.
  7. Ross RR. Effectiveness of immunotherapy in the management of insect venom hypersensitivity: A meta-analysis of the literature. May 1997. Data on file with AAAAI and ACAAI and submitted for publication.
  8. Valyaservi MA, Yocum MW, Gosselin VA, Hunt LW. Systemic reactions to immunotherapy at the Mayo Clinic. J Allergy Clin Immunol 1997; 99:S66.
  9. Van Arsdel PP, Sherman WB. The risk of inducing constitutional reactions in allergic patients. J Allergy 1957; 28:251-261.
  10. Turkeltaub P. Deaths associated with allergenic extracts. FDA Medical Bulletin 24, May 1994.
  11. Data on file with the Allergen Products Manufacturers Association. April 1997 Communication.
  12. Kordash T, Miller J. Allergenic extracts used in immunotherapy fatalities. J Allergy Clin Immunol 1997; 99:S67.
  13. Orange RP, Donsky GJ. Anaphylaxis. In Middleton E, Reed CE, Ellis EF, editors. Allergy: principles and practice. St. Louis 1978, Mosby.
  14. Idsoe O, Gruthe T, Wilcox RR, et al. Nature and extent of penicillin side-reactions with particular references to fatalities from anaphylactic shock. Bull WHO 1968; 38:159.
  15. Shehadi WH. Death following intravascular administration of contrast media. Acta Radiol Diagn 1982; 26:457-61.
  16. Hartman GW, Hattery RR, Witten DM, Williamson B. Mortality during excretory urography: Mayo Clinic Experience. AJR 1982; 139:919-922.
  17. Katayama H, Yamaguchi K, Kozuka T, et al. Reactions to ionic and nonionic contrast media: A report from the Japanese Committee on the Safety of Contrast Media. Radiology 1990; 175:621-628.
  18. Joint task force on practice parameters representing the American Academy of Allergy, Asthma & Immunology and the American College of Allergy, Asthma & Immunology. Nichlas RA, Bernstein IL, Blessing-Moore J, Fineman S, editors. J Allergy Clin Immunol 1996; 98:1-11.
  19. Executive Committee, American Academy of Allergy, Asthma & Immunology. The waiting period after allergen skin testing and immunotherapy. J Allergy Clin Immunol 1990; 85:526-527.
  20. Board of Directors, American Academy of Allergy, Asthma & Immunology. Position Statement. Guidelines to minimize the risk from systemic reactions caused by immunotherapy with allergenic extracts. J Allergy Clin Immunol 1994; 93:811-812